New strategies for macromolecular complexes analysis. Symposium

Protein engineering and production are essential tools for structural, biophysical and functional studies as well as for biotechnology and medical applications. Although strategies and technologies to produce proteins and complexes have tremendously been improved, in many cases protein production remains a challenge. Know-how of the numerous systems used for protein production is often the key parameter to solve quickly and efficiently bottlenecks.

The meeting is dedicated to modern methods in sample preparation and characterization of proteins for structural studies. It will cover state-of-arts strategies used to answer challenges associated with sample preparation for structural and biochemical studies.

Lectures will also include applications that illustrate the impact of directed evolution for sample optimization and synthetic biology for analysis of large assemblies whose activities can be regulated upon ligand binding or by post-translational modifications.

The meeting will be divided in two parts: a symposium and a practical workshop.